爱思益普为您提供激酶谱筛选,hERG检测、药物筛选、GPCR服务技术特色为:离子通道,激酶谱筛选化合物发现和安全性评价服务。欢迎咨询010-67809840

激酶筛选|药物筛选|hERG检测|离子通道|靶点筛选

钾离子通道

Kv1.1
 

Channel

Kv1.1 (Shaker)

Gene

KCNA1

Sources

human

Expression system

HEK293

Method

whole cell patch clamp

Standard time

2 weeks

Reference compound

4-AP

Target

multiple sclerosis, seizure




Kv1.3
 

Channel

Kv1.3 (Shaw)

Catalog Reference

ICE-HEK-Kv1.3

Gene

KCNA3

Sources

Human

Expression system

HEK293

Method

whole cell patch clamp

Standard time

2 weeks

Reference compound

4-AP,

Target

cancer, obesity, diabetes, asthma, immune system diseases



Kir2.1

Catalog Reference

ICE-HEK-hKir2.1

Gene

KCNJ2

Sources

Human

Expression system

HEK293

Method

whole cell patch clamp

Reference compound

BaCl2(32.4 ± 2.7µM)

Target

Long QT prolongation

 

 blob.png    blob.png

                               blob.png

 

 

 Kir3.1/3.4

 

Channel

Kir3.1/3.4, IKAch

Catalog Reference

ICE-HEK-IKAch

Gene

KCNJ3/KCNJ5

Sources

Human

Expression system

HEK293

Method

whole cell patch clamp

Reference compound

BaCl2(64.4 ± 28.0µM)

Target

Long QT prolongation


blob.png     blob.png


                                                      blob.png

 


Kv1.5
 

Channel

Kv1.5

Gene

KCNA5

Sources

Human

Catalog Reference

ICE-HEK-Kv1.5

Expression system

HEK293

Method

whole cell patch clamp

Standard time

2 weeks

Reference compound

4-AP (9.9μM±15.0μM)

Target

Atrial fibrillation


 blob.png  blob.png


                                               

Kv2.1 



Kv7.1



Kv7.2/7.3 

Channel

KV7.2/7.3, KCNQ2/KCNQ3, M current

Gene

KCNQ2/KCNQ3

Sources

Human

Expression system

HEK293

Method

whole cell patch clamp

Reference compound

Retigabine

Target

Epilepsy


blob.png blob.png

 Kv7.4 

Channel

Kv7.4

Catalog Reference

ICE-HEK-hKCNQ4

Gene

KCNQ4

Sources

Human

Expression system

HEK293

Method

whole cell patch clamp

Reference compound

ML213

Target

Cochlea


blob.png    blob.png    


                                           blob.png

 

 


©2008-2021