ICE BIOSENCE INC.

Home > Services > GPCRs and Kinases > Nuclear Receptors

    Nuclear Receptors

    Nuclear receptors comprise a superfamily of ligand-dependent transcription factors that regulate genetic networks controlling cell growth, development, and metabolism.

    1. Detailed information

    Nuclear receptors comprise a superfamily of ligand-dependent transcription factors that regulate genetic networks controlling cell growth, development, and metabolism. Consisting of 48 members in the human genome the superfamily includes the well-known receptors for steroids, thyroid hormones and vitamins. Members of the nuclear receptor superfamily are characterized by a conserved structural and functional organization consisting of a heterogeneous amino terminal domain, a highly conserved central DNA binding domain (DBD), and a functionally complex carboxy terminal ligand binding domain (LBD).


    ICE Bioscience's established Nuclear receptor List 


    Nuclear receptor family

    Targets

    Thyroid hormone receptor

    TRα, TRβ

    Peroxisome proliferator-activated receptor

    LXRα, LXRβ, FXR, FXR-β

    Retinoic acid receptor

    RARα, RARβ, RARγ

    Liver X receptor-like

     LXRα, LXRβ

    3-Ketosteroid receptors

    GR, MR, PR, AR

    Estrogen receptor

    ERα, ERβ


    image.png

    ©2008-2021