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    Cardiovascular System Pharmacology

    ICE Bioscience's has developed animal models for various cardiac disorders like arrhythmia, myocardial ischemia, heart failure etc.

    1. Detailed information

    ICE Bioscience have a competent & dedicated team working in cardiovascular pharmacology unit. Animal models of cardiovascular system diseases are an important tool for the evaluation of cardiovascular system drugs. In order to evaluate the cardiovascular pharmacology, ICE Bioscience has developed animal models for various cardiac disorders like arrhythmia, myocardial ischemia, heart failure etc.

    1.    Heart failure model:

    2. Increased rear load:

    i) aortic narrowing ii) salt sensitivity HF model.

    3.    Increased front load:

    i) venous fistula method ii) partial valve closure method iii) vein narrowing method.

    4. HF model of reduced myocardial contraction:

    i) coronary artery-causing ischemic cardiomyopathy ii) rapid ventricular pacing method.

    Drug Based Models

    ICE Bioscience INC has established Heart Failure (HF) models by using Sodium pentobarbital, Ethanol, Verapamil, Propranolol, Daunorubicin, Adriamycin and Isoprenaline. These drugs induced the decreased myocardial contraction leading to HF model.

    1.  Arrhythmia model:

    These are the strong Arrhythmia models.

    Calcium chloride , radon chloride and chloroform model.

    2.   Atrial fibrillation model:

    Myocardial ischemia model


    Evaluation Criteria/Techniques

    ICE Bioscience INC consider these evaluation techniques for the evaluation of cardiac models.

    1.    In Vitro/Ex Vivo.

    Ion Channel Research - Stem Cell Induced Differentiated Cardiomyocytes - Isolated Heart (Langendorff perfusion)

    2.    Hemodynamics.

    Blood pressure and heart rate

    3.     Heart contraction.

    Direct effects on Isolated heart - Animal catheter studies - non-invasive studies of echocardiogram.

    4.    The structure and function of the heart.

    Echocardiogram.



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