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Sodium Channels

    Sodium Channels

     Voltage-gated sodium channels (VGSCs) are responsible for the action potential in the membrane of neurons, cardiac myocytes and most excitable cells.

    1. Detailed information

     Voltage-gated sodium channels (VGSCs) are responsible for the action potential in the membrane of neurons, cardiac myocytes and most excitable cells. They consist of one pore-forming α subunit that associates with other proteins, such as β subunits. The family of sodium channels has nine known isoforms, named NaV1.1 through NaV1.9. VGSCs represent well-precedented drug targets as antidysrhythmics, anticonvulsants and local anaesthetics. West syndrome (also known as infantile spasms), Doose syndrome (also known as myoclonic astatic epilepsy), intractable childhood epilepsy with generalized tonic-clonic seizures (ICEGTC), Panayiotopoulos syndrome, familial hemiplegic migraine (FHM), familial autism, Rasmussens's encephalitis and Lennox-Gastaut syndrome.



    Table: Nav channels classified as TTX-sensitive and TTX-resistant

    Channel isoform

    Distribution

    TTX IC50(nM)

    TTX sensitivity

    Nav1.1

    CNS

    6, (Clare et al.2000)

    TTX-sensitive

    Nav1.2

    CNS

    12, (Catterall et al.2005)

    TTX-sensitive

    Nav1.3

    CNS

    4, (Chen et al.2000)

    TTX-sensitive

    Nav1.4

    Skeletal muscle

    25, (Chahine et al.1994)

    TTX-sensitive

    Nav1.5

    Heart

    2,000, (Clare et al.2000)

    TTX-resistant

    Nav1.6

    CNS

    2.5, (Burbidge et al.2002)

    TTX-sensitive

    Nav1.7

    PNS

    25, (Klugbauer et al.2002)

    TTX-sensitive

    Nav1.8

    PNS

    60,000, (Akopian et al.1996)

    TTX-resistant

    Nav1.9

    PNS

    200,000, (Rugiero et al.2003)

    TTX-resistant

     

    NaV1.7 Assay Data Sheet

    Channel

    Nav1.7

    Gene

    SCN9A (NM_002977)

    Catalog Ref.

    ICE-HEK-Nav1.7

    Sources

    Human

    Expression System

    HEK293

    Method

    whole cell patch clamp

    Standard Time

    2-4 weeks

    Reference Compound

    TTX

    Linked Disorders

    Pain, Anxiety, Depression Related, erythromelalgia

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    Further Details will be provided on request


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