ICE BIOSENCE INC.

Potassium Channels

    Potassium Channels

    Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. They are the most widely distributed types of ion channels, which exi

    1. Detailed information

    Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. They are the most widely distributed types of ion channels, which exist in almost all organisms and are closely related to the formation and regulation of the resting potential of cells.

    The potassium channel family includes more than 70 members of the voltage-gated potassium channel (Kv), the calcium-activated potassium channel (KCa), the introverted rectifier potassium channel (Kir), and the sub-type of double-well potassium channel (K2P).

    The potassium channels are linked with a variety of disorders like seizures, PD, AD, stroke, epilepsy, diabetes, cardiovascular disorders etc. Therefore, target for various drugs.

    ICE has developed a stable expression cell line of nearly 40 human-derived potassium channels for targeted drug screening.

    Potassium Channel Family

    image.png


    Table :ICE established Potassium channel Assay

     

    Family

    Subfamily

    Subtype

    Official Symbol

    Assay method

     

     

     

     

     

     

     

     

     

     

     

    Voltage-gated potassium channels

     

     

     

     

    Kv1

    Kv1.1

    KCNA1

    patch clamp, fluorescence

    Kv1.2

    KCNA2

    patch clamp, fluorescence

    Kv1.3

    KCNA3

    patch clamp, fluorescence

    Kv1.4

    KCNA4

    patch clamp, fluorescence

    Kv1.5

    KCNA5

    patch clamp, fluorescence

    Kv1.6

    KCNA6

    patch clamp, fluorescence

    Kv1.7

    KCNA7

    patch clamp, fluorescence

    Kv1.8

    KCNA8

    patch clamp, fluorescence

    Kv2

    Kv2.1

    KCNB1

    patch clamp, fluorescence

     

    Kv3

    Kv3.1

    KCNC1

    patch clamp, fluorescence

    Kv3.2

    KCNC2

    patch clamp, fluorescence

    Kv3.4

    KCNC4

    patch clamp, fluorescence

    Kv4

    Kv4.2

    KCND2

    patch clamp, fluorescence

    Kv4.3/KChiP2.2

    KCND3

    patch clamp, fluorescence

     

     

     

    Kv7

    Kv7.1

    KCNQ1

    patch clamp, fluorescence

    Kv7.2

    KCNQ2

    patch clamp, fluorescence

    Kv7.3

    KCNQ3

    patch clamp, fluorescence

    Kv7.2/7.3

    KCNQ2/3

    patch clamp, fluorescence

    Kv7.4

    KCNQ4

    patch clamp, fluorescence

    Kv7.5

    KCNQ5

    patch clamp, fluorescence

    Kv7.3/7.5

    KCNQ3/5

    patch clamp, fluorescence

     

    Calcium- and sodium- activated potassium channels

    BKCa

    KCa1.1

    KCNMA1

    patch clamp, fluorescence

     

    SKCa

    KCa2.1

    KCNN1

    patch clamp, fluorescence

    KCa2.2

    KCNN2

    patch clamp, fluorescence

    KCa2.3

    KCNN3

    patch clamp, fluorescence

    IKCa

    KCa3.1

    KCNN4

    patch clamp, fluorescence

     

     

    Inwardly rectifying potassium channels


    Kir2.1

    KCNJ2

    patch clamp, fluorescence

    GIRK

    Kir3.1/3.4

    KCNJ3/5

    patch clamp, fluorescence

    Kir3.2

    KCNJ4

    patch clamp, fluorescence

    KATP

    Kir6.2/Sur1

    KCNJ11

    patch clamp, fluorescence

    Kir6.2/Sur2A

    KCNJ11

    patch clamp, fluorescence

    Two P domain potassium channels

    TASK

    TASK-1

    KCNK3

    patch clamp, fluorescence

    TASK-3

    KCNK9

    patch clamp, fluorescence

    TREK

    TREK-1

    KCNK2

    patch clamp, fluorescence

     


     KV 1.1-1.4 Assay Sheet

    Channel

    Kv1.1-1.4

     

    Gene

    KCNA1 (NM_000217),

    KCNA2 (NM_004974), KCNA3 (NM_002232), KCNA4 (NM_002233)

     

    Catalog Reference

    ICE-HEK-Kv1.1 ICE-HEK-Kv1.2 ICE-HEK-Kv1.3

    ICE-HEK-Kv1.4

    Sources

    Human

    Expression system

    HEK293

    Method

    whole cell patch clamp

    Standard time

    2-4 weeks

    Reference compound

    4-AP

    image.png


    Kv1.5 Assay Data Sheet


    Channel

    Kv1.5

    Gene

    KCNA5

    Catalog Reference

    ICE-HEK-Kv1.5

    Sources

    Human

    Expression system

    HEK293

    Method

    whole cell patch clamp

    Standard time

    2-4 weeks

    Reference compound

    4-AP

    Target

    Atrial fibrillation



    image.png

     



    Please contact us for further details


    • Previous
    • Next
    ©2008-2021