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TRP Channels

    TRP Channels

    The TRP (transient receptor potential) channel is a class of channel proteins that are widely distributed in the peripheral and central nervous system. To date, more than 30 members of the TRP channel

    1. Detailed information

    The TRP (transient receptor potential) channel is a class of channel proteins that are widely distributed in the peripheral and central nervous system. To date, more than 30 members of the TRP channel family have been cloned in mammals.

    TRP ion channels are closely related to a variety of sensory reactions including heat, cold, pain, pressure, smell and taste, and are easily regulated by natural aromatic substances and are the therapeutic targets of many diseases. TRP Ion Channel Family.

    TRP channels are drug targets for pain, anxiety, depression, schizophrenia , tumor and cardiovascular related disorders.

    TRP channel family



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    ICE Established TRP  Channels



    ICE TRP channel panel

    subfamily

    subtype

    Official Symbol

    Assay method

     

     

     

    TRPV

    TRPV1

    TRPV1

    patch clamp, fluorescence

    TRPV3

    TRPV3

    patch clamp, fluorescence

    TRPV4

    TRPV4

    patch clamp, fluorescence

    TRPV6

    TRPV6

    patch clamp, fluorescence

    TRPA

    TRPA1

    TRPA1

    patch clamp, fluorescence

     

     

     

    TRPC

    TRPC3

    TRPC3

    patch clamp, fluorescence

    TRPC5

    TRPC5

    patch clamp, fluorescence

    TRPC6

    TRPC6

    patch clamp, fluorescence

    TRPC7

    TRPC7

    patch clamp, fluorescence

     

     

     

    TRPM

    TRPM2

    TRPM2

    patch clamp, fluorescence

    TRPM4

    TRPM4

    patch clamp, fluorescence

    TRPM7

    TRPM7

    patch clamp, fluorescence

    TRPM8

    TRPM8

    patch clamp, fluorescence





    TRPC6 Assay Data Sheet



    Channel

    TRPC6

    Gene

    TRPC6

    Catalog Reference

    ICE-HEK-TRPC6

    Sources

    Human

    Expression System

    HEK293

    Method

    whole cell patch clamp

    Standard Time

    2-4 weeks

    Reference Compound

    OAG, carbacol

    Linked Disorders

    Tumor Related




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