ICE BIOSENCE INC.

Othter Channels

    Othter Channels

    The hyperpolarization-activated cyclic nucleotide-gated cationic (HCN) channels comprise four members termed HCN1–4

    1. Detailed information

    The hyperpolarization-activated cyclic nucleotide-gated cationic (HCN) channels comprise four members termed HCN1–4 ; they have a pacemaker activity in excitable tissues controlling excitability, establishment of the resting membrane potential, dendritic integration, synaptic transmission and action potential firing.

    ICE has established stable expression cell lines such as HCN1, HCN2, HCN4, etc., in dedication to provide appropriate drug screening services.


    HCN1 Assay Data Sheet

    Channel

    HCN1hyperpolarization activated cyclic nucleotide

    gated potassium channel 1

    Gene

    HCN1 (NM_021072)

    Catalog Reference

    ICE-CHO-HCN2

    Sources

    Human

    Expression system

    CHO

    Method

    whole cell patch clamp

    Standard time

    2-4 weeks

    Reference compound

    Ivabradine

    Target

    Pace maker current of the mammalian heart, bradycardia,

    heart failure

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    Please contact us for further details


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