ICE BIOSENCE INC.

NMDA Receptor Channels

    NMDA Receptor Channels

    The N -methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. The NMDA receptor is one of three types of ionotrop

    1. Detailed information

    The N -methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. The NMDA receptor is one of three types of ionotropic glutamate receptors, the others being the AMPA and kainate receptors. 

    It has imperative physiological role in nervous system development i.e., regulating the survival and development of the neurons,  synaptic plasticity and axon growth etc. It has dynamic role in neuronal circuit development also has vital role in learning and memory process. 

    Functional NMDA receptors contain NR1 subunit, and multiple NR2 subunits to form a quadrat (or penta-polymer) together with NR1.

    NR1 is the basic subunit that makes up the ion channel, NR2 is the regulating subunit. NMDA receptors composed of different NR2 subunits exhibit different intra-brain distribution and physiological characteristics.

    NMDA receptors are target for AD, PD, Depression , Huntington’s disease etc.

    ICE established  stable expression cell line

    Targets

    Official Symbol

    Cells

    Catalog number

    Human NR1/NR2A

    GRIN1/GRIN2A

    HEK293

    ICE-HEK-hNR2A

    Rat NR1/NR2A

    GRIN1/GRIN2A

    HEK293

    ICE-HEK-rNR2A

    Human NR1/NR2B

    GRIN1/GRIN2B

    HEK293

    ICE-HEK-hNR2B

    Rat NR1/NR2B

    GRIN1/GRIN2B

    HEK293

    ICE-HEK-rNR2B

    Human NR1/NR2C

    GRIN1/GRIN2C

    HEK293

    ICE-HEK-hNR2C

    Human NR1/NR2D

    GRIN1/GRIN2D

    HEK293

    ICE-HEK-hNR2D

    AMPA1

    GRIA1

    HEK293

    ICE-HEK-AMPA1

    NMDA(rNR1/2A) Assay Data Sheet

    Channel

    rNR1/2A

    Gene

    GRIN1/GRIN2A

    Catalog Reference

    ICE-HEK-rNR2A

    Sources

    Rat

    Expression system

    HEK293

    Method

    whole cell patch clamp

    Standard time

    2-4 weeks

    Reference compound

    L-Glutamate, Glycine, NVP-AAM077

    Linked Disorders

    Alzheimer’s disease, Parkinson’s disease, Huntington’s

    disease, Depression.


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